Welcome to visit our company Wuhan Newtop Biotech Co., Ltd
Selank
|
Product Name
|
Selank |
|
CAS
|
129954-34-3 |
|
Appearance
|
White powder
|
|
Assay
|
Above 99%
|
|
Test
|
HPLC
|
|
Certificate
|
ISO 9001
|
|
Storage Temperature
|
Keep in a cool, dry, dark location in a tightly sealed container or cylinder.
|
Selank is a synthetic derivative of the tetrapeptide tuftsin that contains a proline-glycine-proline sequence at the C-terminus and has anxiolytic and anti-inflammatory activities. It increases the amplitude and discharge rate of inhibitory postsynaptic currents of neurons in the rat hippocampal CA1 region when used at a concentration of 1 μM. It decreases the level of affective responses and the number of erroneous escape attempts in rats in an acute stress situation, increases orientational-investigative responses of rats in an unfamiliar situation, and reduces the time mice spend immobile in the forced swim test. It increases locomotor activity of high-anxiety Balb/c, but not C57Bl/6, mice in the open field test. Selank (0.01 mg/kg) decreases verticalization induced by apomorphine in mice. It also decreases expression of the inflammation-related genes Il2rg and Xcr1 in mouse spleen after 90 minutes when administered at a dose of 100 μg/kg.
It is known that the classical act via gamma-aminobutyric acid (GABA) type A receptors. They enhance the GABA effect by allosteric modulation, which increases the frequency of opening of channels for ions. The Selank action mechanism may be related to its ability to affect the performance of the GABAergic system.
Wuhan Newtop Biotech Co., Ltd is a professional chemical raw materials manufacturer with many years experince,Our company specializes in exporting high quality Pharmaceutical intermediates,Pharmaceutical raw materials,Safe Organic Solvents, Plant Extract, Spice Auxiliary and Hormones.We have our own delivery line to Canada,USA,UK,Spain, Netherland,Germany,Russia,Kazakhstan,Ukraine,etc.
Door to door without any customs clearance issues. Our products are produced on the basis of best technical team, advanced equipment, high qualified management which meet the requirements of security and environmental protection.
Our Raw Materia Factory
Upstream peptide synthesis
Wuhan Newtop Biotech Co., Ltd production plants are endowed with state-of-the-art equipment for solvent supply, peptide synthesis, purification and isolation of active ingredients and intermediates. All equipment and containment is GMP qualified and cleaning validated. Overlapping capacities and sizes of different equipment trains facilitate a smooth scale-up for increases in demand within the product life cycle.
Downstream purification and isolation of peptides
Wuhan Newtop Biotech Co., Ltd is committed to the systematic expansion and modernization of its purification equipment in order to ensure the efficient production of ever-increasing amounts of bulk peptide pharmaceuticals.It uses sophisticated methods for large scale purification campaigns such as preparative high performance liquid chromatography (HPLC), ion exchange (IEX), size-exclusion chromatography (SEC), and ultra-filtration (UF/TFF). The equipment in place permits highly efficient or even continuous manufacturing of extremely pure products up to multi-kg quantities per lot.For preparative HPLC, dynamic axial compression (DAC) stainless steel columns of up to 60 cm diameter both in batch and continuous mode are packed with the appropriate high performance silica separation phase. For low-pressure chromatography columns up to 80 cm diameter are available. Solvent delivery is ensured from eluent tank farms and containers.The control of microbiological contamination is a prerequisite for API manufacturing. Class D (ISO 8) and C (ISO 7) clean rooms are supplied via HEPA-filtered, temperature and humidity controlled air, down-flow booths are used for minimizing microbial contamination and protecting operators. Highly active pharmaceutical ingredients are handled in integrated safety workbenches or flexible isolators reaching OEB level 4 (1-10 µg/m3).Predefined physicochemical properties of the API can only be achieved by a carefully controlled isolation process. Besides precipitation and crystallization, lyophilization of intermediates and final API is a standard unit operation.
Our R&D Laboratories
Wuhan Newtop Biotech Co., Ltd acquired early mastery of development and manufacturing of peptides, the short chain amino acids linked by peptide bonds that have enabled new generations of small molecule drugs that closely mimic the body's natural pathways.Wuhan Newtop Biotech Co., Ltd possesses first-class capabilities to manufacture peptides at industrial scale and in full compliance with the strictest Good Manufacturing Practice (GMP) standards.
We have sufficient inventory to ensure delivery speed
| If you have any other questions , please feel free to contact with us. |
| |
| Q:Are you a trading company or a manufacturer? |
| A:We are both, so we can always provide wholesale price and most products in stock. |
| |
| Q:How should I pay? |
| A:We accept Bank Transfer and Western union etc. |
| |
| Q:About the delivery |
| A:shipping method are DHL/USPS/FedEx,Delivery time 1-3 working days. |
| |
| Q1:Will you supply samples for testing? |
| A: Free samples for the quality evaluation for most products, but customers only need to undertake the shipping fee for delivery the samples to your door. |
| |
| Q2:What's your MOQ? |
| A: For the high value product, our MOQ starts from 10g,100g and 1kg. |
| |
| Q3:Which kind of payment terms do you accept? |
| A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment |
| by T/T, Western Union ). Bulk order by T/T or L/C. |
| |
| Q4:How about your delivery time? |
| A: Generally, it will take 3 to 5 days after receiving your advance payment. |
| |
| Q5:How do you treat quality complaint? |
| A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss. |
Welcome to be our distinguished customer, please do not hesitate to contact us!
Audited Supplier 
Welcome to visit our company Wuhan Newtop Biotech Co., Ltd
){kind=link}