Tirz is a glucose-dependent in sulin nutrient polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor dual agonist under development for the treatment of type 2 diabetes mellitus. Tirzepatide was significantly more effective in glycemic control and weight loss than dura lutide.
Retatrutide is the newest GLP-1R agonist and was approved by the FDA as a once-weekly injection for the treatment of T2DM in late 2017. The peptide is chemically similar to semaglutid,tirzepatide, with the inclusion of two structural modifications (Lau, Bloch, et al., 2015). The first is the replacement of Gly with the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib) at position 2. The second is the attachment of octadecanoic diacid to the side chain of Lys-26 through a short polyethylene glycol (PEG) spacer and a γ-glutamic acid linker. The amino acid substitution renders the peptide more resistant to DPP-4 compared to liraglutide, and the presence of the 18-carbon fatty acid moiety results in a high binding affinity for serum albumin, which translates to a half-life of approximately 7 days in humans
Raw Powder Liraglutide is a clear, colorless solution. The dosage form is subcutaneous injection. After more than 10 years of research and development, Peptide Liraglutide has many effects such as promoting islet cell regeneration, lowering blood sugar, reducing weight and protecting the cardiovascular system. The brand name Victoza is used to treat type 2 diabetes, and the brand name Liraglutide is used to treat chronic obesity as a supplement for diet control and physical exercise
BENEFITS OF GLP-1 AGONISTS
--Helps slow food leaving your stomach
--Helps prevent your liver from making too much sugar
--Helps the pancreas produce more insul when your blood sugar levels are high
--Can help control blood glucose
--Can reduce hyperglycemia, especially after meals
--Can reduce fasting insul and fasting glucose
--Can reduce hemoglobin A1c
--Can decrease appetite and caloric intake, while inhibiting weight gain
--Has been shown to lower triglyceride levels and oxidative stress from high LDL
--Has been shown to help induce weight loss in obese patients with higher dosing
--Helps decrease leptin and increase leptin sensitivity
--Can increase the conversion of white fat to brown fat
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